Nootropic Powder NSI-189 For Enhance Cognition CAS 1270138-40-3
HOOC (CH2) 7COOH
NSI-189 is a nootropic and neurogenic research chemical derived
from nicotinamide and pyrazine created by Neuralstem, Inc. Research
into NSI-189 has been heavily funded by the Defense Advanced
Research Projects Agency (DARPA) and theNational Institutes of
NSI-189 is a benzylphiperizine-aminiopyridine, nootropic and
neurogenic research chemical created by Neuralstem, Inc. that was
derived from pyrazine and nicotinamide. Studies have shown that it
stimulates neurogenesis of human hippocampus-derived neural stem
cells in vivo and vitro . In healthy adult mice, NSI-189 has been
shown to increase the hippocampal volume by 20% and reverse
behavioral symptoms in mouse depression models, meaning at the
source it could address depression . The hippocampus is responsible
for spatial navigation, along with the consolidation of information
from short-term memory to long-term memory.
The chemical entity stimulates new neuron growth in the
hippocampus, which is an area of the brain that is believed to be
contributory in conditions such as post-traumatic stress disorder
(PTSD), Alzheimer's disease, and major depressive disorder (MDD).
NSI-189 is neurogenic and nootropic research agent that was
developed from nicotinamide and pyrazine. Randomized controlled
trials have shown that it stimulates neurogenesis or neuronal cell
production in the brain. In animal studies, it has also been shown
to increase the volume of hippocampus by 20% thereby reversing
behavioral symptoms of depression. Such studies have shown that it
may be an effective treatment for depression. It is also thought to
be a promising treatment for other condition including
post-traumatic stress disorder (PTSD), Alzheimer's disease and
age-related cognitive problems.
NSI-189 has been proved that is thought to potentially promote
increased neuronal production whilst treat depression is NSI-189.
This article discusses NSI-189 and how this novel nootropic agent
can revolutionize the treatment for depression, and possibly other
Current treatments for major depressive disorder (MDD) mostly
include the use of oral medications to modulate critical
neurotransmitters in the brain. Selective serotonin reuptake
inhibitors (SSRIs) are believed to be the most commonly and widely
prescribed treatment for depression. Most recent research however
reveals that there is a new theory regarding the cause of major
depressive disorder. This theory implicates that brain physiology
also influences depression rather than brain chemistry problems
Researchers have discovered that the disease leads to decreased
hippocampal volume. Note that a healthy hippocampus is an excellent
source of neural stem cells which lead to the production of
neurons. Neurons on the other hand are critical for creating
essential new connections in the brain. Through the production of
new neurons in the hippocampal area, depression can be treated.
NSI-189's Method of Action
Although it has been demonstrated in rats and chimps, the
suggestion that having too small of a hippocampus causes depression
and other diseases in humans is still technically just a theory.
NSI-189 increases hippocampal volume in adult mice by 20%, a region
of the brain that is one of the first to suffer damage resulting in
memory loss, disorientation, encephalitis, and hypoxia from
disease's such as
1) Enhance cognition and memory formation.
2) Anxiolytic properties.
3) Anti-depressive effect .
4) Treatment of Alzheimer's and Parkinson's disease.
5) Increase coordination.
6) Improves mood.
7) Help fight fatigue.
8) Prevent oxidation within the brain.
9) Treat alcohol related brain damage.
How NSI-189 works
This drug was developed to address three important aspects of
depression including hippocampal volume, neurogenesis and
neurotransmission. NSI-189 increases the volume within the
hippocampus. In so doing, hippocampal volume and healthy brain cell
density is increased thereby improving mod and cognitive
performance. Aside from increasing hippocampal volume, the drug
also improves neuronal cell functionality. It works it promoting
healthy neuronal cell growth whilst repair damaged areas in the
Dosage and Suggestion
Studies conducted to evaluate effects of NSI-189 revealed that 40
to 80 mg daily is effective in treating depression and cognitive
symptoms amongst healthy patients. In these trials, there are no
serious adverse events recorded. Generally, NSI-189 is well
tolerated and safe for human use.
Tests have shown that NSI-189 significantly improved behavioral
responses that are associated with
depression . In humans it may counter hippocampal atrophy which is
seen in disorders such as MDD, reversing their symptoms. A phase 1B
randomized, double-blind, placebo-controlled,multiple-dose
escalation study conducted over a 28 day period showed behavioral
efficacy in 24 patients who were orally administered NSI-189. The
efficacy measurements showed a clinically meaningful reduction in
cognitive and depressive symptoms across all measures, and appeared
to persist over time during follow up for the efficacy assessments
which included the Clinical Global Impression - Improvement
(CGI-I), Montgomery-Aserb Depression Rating Scale (MADRS),
Cognitive and Physical Functioning Questionnaire (CPFQ, and the
Symptoms of Depression Questionnaire (SDQ)
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