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Active Pharmaceutical Ingredients Meclofenoxate hydrochloride CAS 3685-84-5 cerebral stimulant

Categories Active Pharmaceutical Ingredients
Brand Name: NJBN STEROID
Model Number: 3685-84-5
Certification: ISO9001, KOSHER, GSG
Place of Origin: MADE IN CHINA
MOQ: 10g
Price: 2000kg/month
Payment Terms: Western Union, T/T, MoneyGram, Bitcoin
Supply Ability: 2000kg/month
Packaging Details: 100g, 1kg/ foil bag; 10kg/25kg/drum
Name: Centrophenoxine,
Color: White powder
Function: cerebral stimulant and Acetylcholine precursor
CAS: 3685-84-5
Purity: 99%
EINECS: 222-975-3
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Active Pharmaceutical Ingredients Meclofenoxate hydrochloride CAS 3685-84-5 cerebral stimulant


Active Pharmaceutical Ingredients Meclofenoxate hydrochloride CAS 3685-84-5 cerebral stimulant


  • Quick Details of Active Pharmaceutical Ingredients Meclofenoxate hydrochloride

Product Name: Meclofenoxate hydrochloride

Synonyms: (p-chlorophenoxy)aceticacid2-(dimethylamino)ethylesterhydrochloride;235anphydrochloride;acefen;aceticacid,(4-chlorophenoxy)-,2-(dimethylamino)ethylester,hydrochloride;aceticacid,(p-chlorophenoxy)-,2-dimethylaminoethylester,hydrochloride;amipolen;brenal;cellative;


CAS: 3685-84-5;

MF:C12H17Cl2NO3;

EINECS: 222-975-3;

MW: 294.17.


Product name:Meclofenoxate hydrochloride
Other Name:(p-chlorophenoxy)aceticacid2-(dimethylamino)ethylesterhydrochloride;235anphydrochloride;acefen;aceticacid,(4-chlorophenoxy)-,2-(dimethylamino)ethylester,hydrochloride;aceticacid,(p-chlorophenoxy)-,2-dimethylaminoethylester,hydrochloride;amipolen;brenal;cellative;
Original:China
CAS:3685-84-5
Molecular formula:C12H17Cl2NO3
MW:294.17
EINECS:222-975-3
Brand nameNJBNSteroid
Leading timewithin 24 hours upon receipt of payment
DeliveryFast and secure shipping by EMS, DHL, TNT, FedEx, UPS
Purity99%
PackageDiscreet and Hidden package according to specific requirement
AppearanceWhite Powder
CertificationSGS, ISO 9001, KOSHER
Payment TermsWestern Union, Money Gram , T/T, Bitcoin
Minimum Order Quantity5g
PriceNegotiable
UsageMeclofenoxate is a cerebral stimulant. Also, Meclofenoxate is used as plant growth regulator.
Molecular structure



  • Description of Active Pharmaceutical Ingredients Meclofenoxate hydrochloride

1. Meclofenoxate (INN, BAN), also known as centrophenoxine, is a cholinergic nootropic used as a dietary supplement and drug in the treatment of symptoms of senile dementia and Alzheimer's disease. It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA). DMAE is a natural substance, found especially in fish, while pCPA is a synthetic compound that resembles a variety of plant hormones called auxins.


2. In elderly patients, meclofenoxate has been found clinically to improve memory, have a mentally stimulating effect, and improve general cognition. Meclofenoxate also increases cellular membrane phospholipids. Although meclofenoxate is generally considered to be a dietary supplement, in some European countries, such as Germany, Hungary, and Austria, as well as Japan, it is a prescription drug.


  • Technical Test Sheet of Active Pharmaceutical Ingredients Meclofenoxate hydrochloride


Test/ObservationSpecificationsResult
Assay Content % by HPLCMin.98%99.08%
Appearancewhite powderComplies
OdorCharacteristicComplies
PH5.0-7.06.09
Clarity of water solutionTransparent, colorless, none suspended mattersComplies
Loss on drying %MAX 0.50.25
Ash %MAX.0.50.38
Melting point+202.0-212.0 ℃Complies
Specific rotation+174.0-+186.0+181.0
Heavy metals PPMMAX.10Complies
As AAS
Pb
Cd
<2ppm
<1ppm
<1ppm
Complies
Complies
Complies
Microbiology
Total Plate Count
Yeast & Mold
E.Coli
S. Aureus
Salmonella

<1000cfu/g
<100cfu/g
Negative
Negative
Negative


122 cfu/g
13 cfu/g
Complies
Complies
Complies

ConclusionConform with specification

  • Medical Usage of Active Pharmaceutical Ingredients Meclofenoxate hydrochloride

1. Meclofenoxate, also called centrophenoxine, is a drug prescribed for the treatment and management of Alzheimer’s disease and senile dementia. It has shown to have the ability to rid the brain of lipofuscin/beta-amyloid pigmentation build-up thereby slow down and even the reverse the effects of aging on the brain. It is currently investigated for its potential as a treatment for a number of other cognitive disorders.


2. Meclofenoxate hydrochloride, an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA), has been shown to improve memory, have a mentally stimulating effect, and improve general cognition.


3. This drug is also being marketed as a nootropic enhancer with the ability to help improve memory and prevent memory loss among the elderly. Meclofenoxate increases the dimethylethanolamine or DMAE levels in the brain. DMAE is a precursor of acetylcholine, an important neurotransmitter in the brain believed to be responsible for most of the cognitive processes within it.


4. It is regarded in many ways as a more effective version of DMAE and an excellent source of choline for your brain. Meclofenoxate also possesses significant anti-aging properties that can improve the health of your neurons and boost cellular function.


5. Centrophenoxine removes lipofuscin, potassium age pigment from the brain, heart and skin. Appearances of lipofuscin in the skin are referred to as liver, or age spots. Lipofuscin occurs in much higher levels in Alzheimer's patients than in their counterparts, and some theories relate brain and memory function to the ability of potassium to enter and exit brain cells. As we age, this ability is reduced and potassium levels rise. Centrophenoxine can also increase production of brain RNA and aid in a patient's oxygen consumption and carbon dioxide production.


6. Centrophenoxine's possible anti-aging benefits include protection against free radical damage in the brain, increased potential life span, reduction and prevention of age spots in skin, increased mental energy, improved memory, and prevention and treatment of stroke and brain injury.


  • Biological activity of Active Pharmaceutical Ingredients Meclofenoxate hydrochloride


1. Meclofenoxate hydrochloride, an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA), has been shown to improve memory, have a mentally stimulating effect, and improve general cognition.
IC50 value:
2. Target: nootropic
Meclofenoxate, administered in a dose of 50 mg/kg twice daily for 7 days using the maze-training method, increased the number of responses to the conditioned stimulus, when retention tests were made 24 hours and 7 days after training, whereas citicholine, applied in the same way in a dose of 10 mg/kg, shortened the latency of the responses with reinforcement during the training and increased the number of correct responses to the conditioned stimulus in retention tests 7 days after the training [1]. Meclofenoxate appears to increase the consolidation of new information into long-term memory, but does not affect other aspects of remembering .


  • Side Effect of Active Pharmaceutical Ingredients Meclofenoxate hydrochloride

Meclofenoxate is considered to be very safe and high in tolerability. However, possible side effects may include, rarely, insomnia, dizziness, restlessness, muscle tremor, depression, nausea, muscle tension, and headache; these side effects may due to overdosage, and may indicate the need for the dosage to be reduced.


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