Terlipressin for Norepinephrine-Resistant Septic Shock Aggregation
Appearance: white crystal powder.
USES: vasoconstriction medicine and positive inotropic drug. Drug
interactions can heighten the stroke turned their hearts, also can
reduce, the result depends on vascular resistance size, left the
stand or fall of cardiac function and all kinds of the reflection
of the weak.
1. soluble in mineral acids and alkali hydroxide solution, slightly
soluble in water, soluble in alcohol, ether, acetone, chloroform.
Odorless, bitter taste. Exposed in the air and see the light color
2. epinephrine (adrenaline, epinephrine, capital abbreviations are: A
or E) is the main hormone of the adrenal medulla, the biosynthesis
mainly in the medulla chromaffin cells norepinephrine first formed,
then further through phenethylamine -N- methyl transferase
(phenylethanolamine N-methyl transferase, PNMT) the role of the
norepinephrine methylated form of adrenaline.
3. L(-)-Epinephrine Usage: non-steroidal hormone drugs, also used as a
hemostatic Adrenosem intermediates. Mainly used for anaphylactic
shock, bronchial asthma and cardiac arrest rescue. The main
clinical use of cardiac arrest, bronchial asthma, anaphylactic
shock, but also treat hives, hay fever and nasal or gum bleeding.
4. The direct effect of the product on the adrenergic α, β receptors,
resulting in rapid and brief strong excitement α and β-type effect
on the heart β1- receptors excited, can enhance myocardial
contractility, heart rate, cardiac increased oxygen consumption. At
the same effect on vascular smooth muscle β2- receptor, blood
vessels dilate, reduce peripheral vascular resistance and reduced
diastolic blood pressure. Β2- excited receptors in bronchial smooth
muscle relaxation, bronchodilation, relieve bronchial spasm; for α-
receptor stimulant, the skin, mucosal vascular and visceral small
|Characters||White or greyish-white crystalline odorless soluble|
powder,freely soluble in acid water,slightly
in alcohol ,practically insoluble in ether.
|Identificaion||0.10N iodine deep red color||validity|
|Specific rotaion||Between -50.0°and -53.5°||-51.0°|
|Loss on drying||Not more than 2.0%||0.5%|
|Residue on lgnition||Negligible||Negligible|
|Limit of adrenalone||At 310 nm not more than 0.20||0.027|
|Limit of noreponephrine||Not more than 4.0%||1.0%|
|Assay||Not less than 97.0% and not more than 102.0%||99.9%|
|Residula solvents||Methanol: not more than 3000ppm||Methanol:1500ppm|
|Storage||Store in vacuum and protected from light|
|CONCLUSION:||The above product complies with the standard of contract. UPS32|
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